Perfluorooctanoic acid disrupts hepatic metabolism in the developing chicken embryo
In ovo exposure to PFOA disrupts hepatic metabolism in developing chicken embryos, particularly through alterations in bile acid, lipid, and amino acid pathways. These metabolic changes may impair energy production, endocrine regulation, and organ development, with possible long-term health consequences.
Authors
- Alex M. Dickens (ORCID: https://orcid.org/0000-0002-3178-8449)
- Tuulia Hyötyläinen (ORCID: https://orcid.org/0000-0002-1389-8302)
- Nikolai Scherbak (ORCID: https://orcid.org/0000-0001-9713-2365)
- Matilda Kråkström (ORCID: https://orcid.org/0000-0001-7956-958X)
- Matej Orešič (ORCID: https://orcid.org/0000-0002-2856-9165)
- Daniel Duberg (ORCID: https://orcid.org/0000-0003-4815-9689)
- Magnus Engwall
- Pauli Tikka
Institutions
- Åbo Akademi University (FI)
- University of Turku (FI)
- Örebro University (SE)
- Turku Centre for Biotechnology (FI)
Publication Details
- Journal
- Metabolomics
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1007/s11306-025-02374-5
- Primary Topic
- Per- and polyfluoroalkyl substances research
- Type
- article
- Field-Weighted Citation Impact
- 0.00