Impact of variants of uncertain significance on decision making about genetic testing for Hispanic males
Although many Hispanic males are interested in genetic testing despite the higher likelihood of VUS, potential consequences include decisional regret, anxiety, and even changes in behavior. Effective counseling and support are important for minoritized groups undergoing genetic evaluation to avoid the potential to exacerbate health disparities.
Authors
- Michele Santacatterina (ORCID: https://orcid.org/0000-0003-0599-3876)
- Jasmine Saunders (ORCID: https://orcid.org/0009-0005-1098-8643)
- Stacy Loeb (ORCID: https://orcid.org/0000-0003-3933-9207)
- Susan T. Vadaparampil (ORCID: https://orcid.org/0000-0002-1052-6917)
- Nataliya Byrne (ORCID: https://orcid.org/0000-0002-6376-5444)
- Veda N. Giri (ORCID: https://orcid.org/0000-0002-7268-5913)
- Kellie Owens (ORCID: https://orcid.org/0000-0002-2602-5762)
- Tatiana Sanchez Nolasco (ORCID: https://orcid.org/0000-0002-8402-1508)
- Mariana Rangel Camacho
- Adrian Rivera (ORCID: https://orcid.org/0009-0006-2209-0686)
Institutions
- Yale Cancer Center (US)
- Moffitt Cancer Center (US)
- NYU Langone Health (US)
Publication Details
- Journal
- Genetics in Medicine Open
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1016/j.gimo.2025.103480
- Primary Topic
- BRCA gene mutations in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00