Effect of diamine oxidase (DAO) enzyme dietary supplementation in subjects with insomnia symptoms and single nucleotide polymorphisms of the AOC1 gene: a randomized double-blind placebo-controlled study
In this exploratory study, the use of a DAO supplement for 28 days improved insomnia symptoms in the presence of genetic variants of the <i>AOC1</i> gene and showed a synergy with melatonin.Registered in the ClinicalTrials.gov (NCT07027943).
Authors
- Karol Uscamaita (ORCID: https://orcid.org/0000-0003-4846-8959)
- Georgia Gris
- Raquel López García (ORCID: https://orcid.org/0000-0002-0053-9335)
- María Dolores Navarro
- Anna Sansalvador
- Montserrat Abadías
- Júlia Ferrer-Garcia (ORCID: https://orcid.org/0009-0000-4836-2463)
Institutions
- Hospital Sant Joan de Déu Barcelona (ES)
- Agència de Qualitat i Avaluació Sanitàries de Catalunya (ES)
- Hospital Universitari Sagrat Cor (ES)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- Sleep Medicine X
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1016/j.sleepx.2025.100167
- Primary Topic
- Polyamine Metabolism and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00