Extraintestinal Manifestations and Cytomegalovirus Reactivation Are Predictors of Difficult-To-Treat in Ulcerative Colitis
Among patients with UC, the presence of EIM and CMV reactivation was significantly associated with steroid dependence, steroid refractoriness, and resistance to biologic and molecular-targeted therapies.
Authors
- Hiroshi Nakase (ORCID: https://orcid.org/0000-0003-2848-6586)
- Tomoe Kazama
- Kotaro Akita (ORCID: https://orcid.org/0009-0006-8687-3508)
- Hiroki Kurumi (ORCID: https://orcid.org/0000-0002-2372-1631)
- Yoshihiro Yokoyama (ORCID: https://orcid.org/0000-0003-2434-1048)
- Masanori Nojima (ORCID: https://orcid.org/0000-0002-8788-2522)
- Yuta Shimomori
- Mayuko Erata
Institutions
- Sapporo Medical University (JP)
- University of Tokyo Hospital (JP)
- Tottori University (JP)
Publication Details
- Journal
- Inflammatory Intestinal Diseases
- Published
- 2025-11-27
- DOI
- https://doi.org/10.1159/000549366
- Primary Topic
- Cytomegalovirus and herpesvirus research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministry of Health, Labour and Welfare
- Japan Society for the Promotion of Science