Revisiting the Obesity Paradox: Stroke Subtype-Specific Associations of BMI and WHR with Functional Outcome
BMI and WHR show distinct, nonlinear, and sex- and subtype-specific associations with stroke severity and functional outcome. WHR was a stronger, BMI-independent predictor of prognosis, particularly in non-cardioembolic stroke. These findings challenge the "obesity paradox" and support incorporating adiposity phenotypes into individualized stroke risk models.
Authors
- Thomas Karrasch (ORCID: https://orcid.org/0000-0001-6850-588X)
- Tobias Braun (ORCID: https://orcid.org/0000-0003-1738-2773)
- Michael Buerke (ORCID: https://orcid.org/0009-0009-5477-9957)
- Priyanka Boettger (ORCID: https://orcid.org/0009-0004-0534-132X)
- Omar Alhaj Omar (ORCID: https://orcid.org/0009-0007-1932-4303)
- Martin Juenemann (ORCID: https://orcid.org/0000-0002-8905-3138)
- Jamschid Sedighi (ORCID: https://orcid.org/0009-0007-9107-8063)
Institutions
- Justus-Liebig-Universität Gießen (DE)
- Malteser Krankenhaus St. Anna (DE)
Publication Details
- Journal
- Cerebrovascular Diseases Extra
- Published
- 2025-11-27
- DOI
- https://doi.org/10.1159/000549790
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Justus Liebig Universität Gießen