Associations Between Chronic Conditions and Physical-Cognitive Performance in Middle-Aged Adults: A Cross-Sectional Analysis

The global rise in chronic noncommunicable diseases poses a growing challenge to healthcare systems, particularly in developing countries. This cross-sectional study aimed to investigate the associations between chronic diseases and mobility, balance, and visual memory in middle-aged adults. Ninety-seven participants aged 40-64 were categorized based on the Age-Adjusted Charlson Comorbidity Index. Assessments included the Timed Up and Go Test for mobility, the One-Leg Standing Balance Test for static balance, the Y Balance Test for dynamic balance, and the Rey-Osterrieth Complex Figure Test for visual memory. Individuals with chronic diseases had significantly lower scores in all outcome measures compared to those without (<i>P</i> < .05). However, after adjusting for confounders such as age, body mass index, education, and employment status, group differences were no longer statistically significant. Age, education level, static balance, and right foot dynamic balance were significantly associated with mobility. The results highlight the need for early assessment and preventive strategies targeting mobility, balance, and cognitive functioning in middle-aged individuals with chronic diseases.