EMP1 + hepatic stellate cells drive hepatic fibrosis progression to hepatocellular carcinoma and predict prognosis
This study, through the integration of multi-omics data, establishes EMP1 as a reliable marker of activated HSCs. The genes NPY1R, CTHRC1, IGFBP3, and ADH1B play critical regulatory roles and exhibit prognostic value in the progression from hepatic fibrosis to HCC. Our findings provide novel insights and therapeutic targets for the use of Salvia miltiorrhiza in treating hepatic fibrosis and HCC.
Authors
- Jia Yao (ORCID: https://orcid.org/0000-0003-1457-7241)
- Yasong Liu (ORCID: https://orcid.org/0000-0002-9919-2051)
- Yihuan Huang
- Chenhao Jiang
- Jiebin Zhang (ORCID: https://orcid.org/0000-0002-2650-6822)
- Yingcai Zhang (ORCID: https://orcid.org/0000-0002-3086-2440)
- Xin Sui (ORCID: https://orcid.org/0000-0002-6830-7012)
- Tongyu Lu (ORCID: https://orcid.org/0009-0000-9812-5415)
- Jie You (ORCID: https://orcid.org/0000-0002-4657-6377)
- Jiaqi Xiao (ORCID: https://orcid.org/0000-0002-3253-9591)
Institutions
- Sun Yat-sen University (CN)
- Key Laboratory of Guangdong Province (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1186/s12967-025-07454-7
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00