blaKPC-2 amplification and a novel mrcA mutation drive cefiderocol heteroresistance in ST11 CRKP
Amplification of bla<sub>KPC-2</sub> plasmid copy number together with the mrcA G652A mutation drives FDC-HR in CRKP during in vivo evolution. This mechanism may lead to underestimation of resistance by standard susceptibility testing and increase the risk of treatment failure.
Authors
- Qianxuan Dai
- Linping Fan
- Dandan Wei (ORCID: https://orcid.org/0000-0002-5597-6233)
- Yuxuan Liu (ORCID: https://orcid.org/0009-0007-9921-8585)
- Peng Liu (ORCID: https://orcid.org/0000-0002-3347-649X)
- Hanxu Hong (ORCID: https://orcid.org/0009-0005-0937-429X)
- Yang Liu
Institutions
- Nanchang University (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- First Affiliated Hospital of Nanchang University (CN)
Publication Details
- Journal
- International Journal of Antimicrobial Agents
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1016/j.ijantimicag.2025.107682
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00