Reactogenicity and immunogenicity following heterologous and homologous third dose COVID-19 vaccination in UK adolescents (Com-COV3): A randomised controlled non-inferiority trial
All booster regimens evaluated elicited a robust immune response. 10 μg fractional adult BNT162b2 vaccine demonstrated similar immunogenicity compared with 30 μg BNT162b2 and superior immunogenicity compared with 10 μg paediatric BNT162b2 vaccine. Fractional doses of the adult BNT162b2 vaccine are an alternative to the paediatric formulation for booster campaigns in adolescents.
Authors
- Teresa Lambe (ORCID: https://orcid.org/0000-0001-7711-897X)
- Ralph O. Anslow
- Yama F Mujadidi (ORCID: https://orcid.org/0000-0002-2342-8531)
- Hanane Trari Belhadef
- Jonathan S. Nguyen‐Van‐Tam (ORCID: https://orcid.org/0000-0003-2579-4655)
- Liberty Cantrell (ORCID: https://orcid.org/0000-0001-5413-7641)
- SN Faust
- Paul T. Heath (ORCID: https://orcid.org/0000-0002-7540-7433)
- James Cotton (ORCID: https://orcid.org/0000-0001-6548-2723)
- Matthew D. Snape (ORCID: https://orcid.org/0000-0003-0531-5426)
- Fiona Shackley
- Elizabeth Clutterbuck (ORCID: https://orcid.org/0000-0003-1701-1390)
- Parvinder K. Aley (ORCID: https://orcid.org/0000-0002-0749-8329)
- Theofilos Polychronakis (ORCID: https://orcid.org/0000-0002-8650-4095)
- Katrina Cathie (ORCID: https://orcid.org/0000-0001-5074-0769)
- Angela M. Minassian (ORCID: https://orcid.org/0000-0001-7832-9824)
- Claire Cameron (ORCID: https://orcid.org/0000-0002-2151-4137)
- Grace C. Macaulay (ORCID: https://orcid.org/0000-0003-2641-3359)
- Mary Ramsay (ORCID: https://orcid.org/0000-0002-7156-7640)
- Philip de Whalley
- Elizabeth J. Kelly (ORCID: https://orcid.org/0000-0002-6988-8576)
- Tim James (ORCID: https://orcid.org/0000-0002-5382-9838)
- Melanie Greenland (ORCID: https://orcid.org/0000-0001-9363-8844)
- Stephen M. Riordan (ORCID: https://orcid.org/0000-0002-5120-691X)
- Stephen Owens (ORCID: https://orcid.org/0000-0002-6979-9207)
- Bassam Hallis
- Lei Chang (ORCID: https://orcid.org/0000-0002-9824-4016)
- Robert C. Read (ORCID: https://orcid.org/0000-0002-4297-6728)
- James Kinch
- Yang Liu (ORCID: https://orcid.org/0000-0002-0367-8189)
- Emma Plested
- Banerjee
- Anirban Singha
- Philip Connor
- S Koleva
- M Matheson
- Turner Dpj
- T Madupuri
Institutions
- Nottingham University Hospitals NHS Trust (GB)
- University of Nottingham (GB)
- St George's, University of London (GB)
- Royal Free London NHS Foundation Trust (GB)
- Leeds Teaching Hospitals NHS Trust (GB)
- Health Protection Scotland (GB)
- University Hospital of Wales (GB)
- St George’s University Hospitals NHS Foundation Trust (GB)
- Newcastle upon Tyne Hospitals NHS Foundation Trust (GB)
- Cambridge University Hospitals NHS Foundation Trust (GB)
- University Hospital Southampton NHS Foundation Trust (GB)
- Public Health England (GB)
- University of Oxford (GB)
- Noah's Ark Children's Hospital for Wales (GB)
- NIHR Southampton Biomedical Research Centre (GB)
- Sheffield Children's NHS Foundation Trust (GB)
- Oxford BioMedica (United Kingdom) (GB)
- Science Oxford (GB)
- Oxford University Hospitals NHS Trust (GB)
- Royal Manchester Children's Hospital (GB)
- UK Health Security Agency (GB)
Publication Details
- Journal
- Journal of Infection
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1016/j.jinf.2025.106663
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00