BER-Ago: A simultaneous detection and inhibitor screening platform for multiple base excision repair proteins
• BER-Ago was proposed to detect four non-nucleic acid targets simultaneously. • BER-Ago assay could be repurposed to evaluate and screen potential inhibitors for four BER proteins. • BER-Ago offers a new insight into the developments of Ago-based tools for biosensing and therapeutic applications.
Authors
- Dianxiang Lu (ORCID: https://orcid.org/0000-0001-5677-2833)
- Ting Zhu (ORCID: https://orcid.org/0000-0003-4149-2710)
- Yang Jin (ORCID: https://orcid.org/0000-0002-7996-048X)
- Jia Wei (ORCID: https://orcid.org/0000-0002-9634-9439)
- Chen Ju (ORCID: https://orcid.org/0000-0001-8472-7677)
- Xiao Song (ORCID: https://orcid.org/0000-0001-7440-2756)
- Huijuan Li (ORCID: https://orcid.org/0000-0002-5542-9950)
- Shaozhen Ding
Institutions
- Chengdu Medical College (CN)
- Chengdu University of Technology (CN)
- Chengdu University (CN)
- First Affiliated Hospital of Chengdu Medical College (CN)
Publication Details
- Journal
- Journal of Pharmaceutical Analysis
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1016/j.jpha.2025.101507
- Primary Topic
- Protein Degradation and Inhibitors
- Type
- article
- Field-Weighted Citation Impact
- 0.00