Cost-Effectiveness of Pantoprazole to Prevent Upper Gastrointestinal Bleeding in Mechanically Ventilated Patients
In this economic evaluation, daily pantoprazole for invasively mechanically ventilated patients was less costly and more effective than care without pantoprazole, indicating both clinical benefits and economic value for the health care system.
Authors
- Serena Knowles (ORCID: https://orcid.org/0000-0002-5028-3825)
- Patrick Archambault (ORCID: https://orcid.org/0000-0002-5090-6439)
- Arnold S. Kristof (ORCID: https://orcid.org/0000-0003-2980-8540)
- Steven Reynolds (ORCID: https://orcid.org/0000-0002-2624-640X)
- Nicole Zytaruk
- Laurent Billot (ORCID: https://orcid.org/0000-0002-4975-9793)
- Simon R. Finfer (ORCID: https://orcid.org/0000-0002-2785-5864)
- François Lauzier (ORCID: https://orcid.org/0000-0002-6530-5513)
- Karen E. A. Burns (ORCID: https://orcid.org/0000-0002-9967-5424)
- Shane English (ORCID: https://orcid.org/0000-0002-9477-6146)
- Eric Sy (ORCID: https://orcid.org/0000-0001-5033-797X)
- Alexis Poole (ORCID: https://orcid.org/0000-0002-3345-1356)
- Brenda Reeve (ORCID: https://orcid.org/0000-0002-7829-303X)
- John Myburgh (ORCID: https://orcid.org/0000-0003-4088-7016)
- Gilmar Reis (ORCID: https://orcid.org/0000-0002-4847-1034)
- Waleed Alhazzani (ORCID: https://orcid.org/0000-0001-8076-9626)
- Yue Ma (ORCID: https://orcid.org/0000-0003-1362-3752)
- Paul Hosek
- Yaseen M. Arabi (ORCID: https://orcid.org/0000-0001-5735-6241)
- Kosar Ali Khwaja (ORCID: https://orcid.org/0000-0002-1660-3565)
- Vincent Issac Lau (ORCID: https://orcid.org/0000-0002-9939-7348)
- Alexandra Binnie (ORCID: https://orcid.org/0000-0003-2969-8177)
- Yanbin Yao (ORCID: https://orcid.org/0000-0003-3838-4305)
- David R. Williamson (ORCID: https://orcid.org/0000-0003-3360-4831)
- Alberto Goffi (ORCID: https://orcid.org/0000-0002-9658-3903)
- Mark Tutschka
- Ian Ball (ORCID: https://orcid.org/0000-0002-8503-2153)
- Charles St. Arnaud
- M.J. Hardie (ORCID: https://orcid.org/0000-0003-2687-4622)
- Lehana Thabane (ORCID: https://orcid.org/0000-0003-0355-9734)
- Sébastien Trop
- Gordon Guyatt (ORCID: https://orcid.org/0000-0003-2352-5718)
- Robert Cirone
- Jeffrey F. Barletta (ORCID: https://orcid.org/0000-0002-9054-8218)
- William R. Henderson (ORCID: https://orcid.org/0000-0002-7744-0245)
- Oleksa Gregory Rewa (ORCID: https://orcid.org/0000-0002-8718-0547)
- Salmaan Kanji (ORCID: https://orcid.org/0000-0003-0594-0360)
- Brittany Humphries (ORCID: https://orcid.org/0000-0001-9364-5788)
- Paul Jeffrey Young (ORCID: https://orcid.org/0000-0002-3428-3083)
- Dorrilyn Rajbhandari
- Richard Hall (ORCID: https://orcid.org/0000-0001-7666-889X)
- Emmanuel Charbonney (ORCID: https://orcid.org/0000-0002-0409-3334)
- Frédérick D’Aragon (ORCID: https://orcid.org/0000-0003-1323-0449)
- David Wayne Johnson (ORCID: https://orcid.org/0000-0001-5491-3460)
- Ryan Zarychanski (ORCID: https://orcid.org/0000-0001-9455-6138)
- David M. Forrest
- Jennifer Tsang (ORCID: https://orcid.org/0000-0002-1809-0505)
- Neill K. J. Adhikari (ORCID: https://orcid.org/0000-0003-4038-5382)
- Bram Rochwerg (ORCID: https://orcid.org/0000-0002-8293-7061)
- Anna Geagea
- Alexandros Cavayas
- Meredith Vanstone (ORCID: https://orcid.org/0000-0002-7347-6259)
- John Muscedere
- Abdulrahman Al‐Fares (ORCID: https://orcid.org/0000-0001-9475-7976)
- Lisa D. Burry (ORCID: https://orcid.org/0000-0002-6545-3890)
- François Marquis
- Daniel Ovakim (ORCID: https://orcid.org/0000-0001-7709-7419)
- Erick Duan (ORCID: https://orcid.org/0009-0008-3573-7754)
- John C. Marshall (ORCID: https://orcid.org/0000-0002-7902-6291)
- Marlies Ostermann (ORCID: https://orcid.org/0000-0001-9500-9080)
- Marianne J. Chapman (ORCID: https://orcid.org/0000-0003-0710-3283)
- Lois Saunders
- Adam M. Deane (ORCID: https://orcid.org/0000-0002-7620-5577)
- Naomi E. Hammond (ORCID: https://orcid.org/0000-0002-6559-7747)
- Kristen Fiest
- France Clarke (ORCID: https://orcid.org/0000-0001-7020-1391)
- Mary Elizabeth Wilcox (ORCID: https://orcid.org/0000-0003-0331-5182)
- Timothy Karachi
- Kathleen Byrne
- Brittany B. Dennis (ORCID: https://orcid.org/0000-0002-3691-5400)
- Tina Mele (ORCID: https://orcid.org/0000-0002-6617-9790)
- Gloria Vázquez‐Grande (ORCID: https://orcid.org/0000-0001-5866-1045)
- Joanna Colleen Dionne (ORCID: https://orcid.org/0000-0002-9401-6868)
- Osama Loubani (ORCID: https://orcid.org/0000-0002-7996-2688)
- Feng Xie (ORCID: https://orcid.org/0000-0003-3454-6266)
- Balasubramanian Venkatesh (ORCID: https://orcid.org/0000-0003-2893-6954)
- Gordon Wood
- Mobeen Iqbal
- Sangeeta Mehta (ORCID: https://orcid.org/0000-0002-7073-4769)
- François Lellouche
- Adam Rahman
- Maureen O. Meade (ORCID: https://orcid.org/0000-0003-1151-0076)
- Robert Fowler
- Ingrid Morgan
- François Lamontagne
- Lori Hand
- Diane Heels‐Ansdell
- Daniel J. Niven
Institutions
- Midwestern University (US)
- St Thomas' Hospital (GB)
- University of Ottawa (CA)
- University of Alberta (CA)
- The University of Melbourne (AU)
- King Saud bin Abdulaziz University for Health Sciences (SA)
- University of Toronto (CA)
- North York General Hospital (CA)
- Ottawa Hospital (CA)
- UNSW Sydney (AU)
- King Abdullah International Medical Research Center (SA)
- The George Institute for Global Health (AU)
- Collaborative Group (United States) (US)
- St. Thomas Hospital (CA)
- Sinai Health System (CA)
- Hôpital du Sacré-Cœur de Montréal (CA)
- Impact (CA)
- Université Laval (CA)
- McGill University (CA)
- The University of Adelaide (AU)
- University of Nebraska Medical Center (US)
- McMaster University (CA)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.52771
- Primary Topic
- Nosocomial Infections in ICU
- Type
- article
- Field-Weighted Citation Impact
- 0.00