POT1-AS1/IGF2BP2/GPX4 promotes temozolomide resistance and radioresistance in glioblastoma by inhibiting ferroptosis
POT1-AS1 promotes TMZ and radiation resistance in GBM by regulating ferroptosis through the IGF2BP2/GPX4 axis. Targeting this pathway may offer a new therapeutic strategy for overcoming GBM treatment resistance.
Authors
- Qiufeng Dong
- Haining Zhen (ORCID: https://orcid.org/0009-0008-2464-7614)
- Zhifeng Yan (ORCID: https://orcid.org/0000-0002-6930-3128)
- Xiaohong Chen (ORCID: https://orcid.org/0000-0002-9797-8384)
- Liwen Li (ORCID: https://orcid.org/0000-0002-1777-2854)
- Juan Li (ORCID: https://orcid.org/0000-0002-8529-2510)
- Junli Huo
Institutions
- Northwest University (US)
- Northwest University (CN)
- Xi'an Medical University (CN)
- Xijing Hospital (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- International Journal of Radiation Biology
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1080/09553002.2025.2588395
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00