Intravenous Thrombolysis Use in the Late Time Window Before Interhospital Transfer for Thrombectomy
In this multicenter cohort study, IVT initiated beyond 4.5 hours prior to interhospital transfer for EVT was associated with higher rates of recanalization during transfer and improved 3-month functional outcomes, without safety concerns. These findings offer encouraging support for clinical trials evaluating IVT in the late time window before interhospital transfer.
Authors
- Maarten G. Lansberg (ORCID: https://orcid.org/0000-0002-3545-6927)
- Pierre Seners (ORCID: https://orcid.org/0000-0002-2134-0691)
- Sam Ghazanfari
- Omar Bennani
- Andrei Girbovan
- Luca Scarcia (ORCID: https://orcid.org/0000-0002-1316-0383)
- Nour Nehme
- Frédérique Charbonneau (ORCID: https://orcid.org/0000-0002-3696-0834)
- Gregory W. Albers (ORCID: https://orcid.org/0000-0003-0263-4632)
- M Dupin
- Olivier Detante (ORCID: https://orcid.org/0000-0001-8761-3288)
- Hilde Hénon (ORCID: https://orcid.org/0000-0001-6274-7562)
- Cyril Chivot (ORCID: https://orcid.org/0000-0002-1829-1200)
- Mathieu Zuber
- Charlotte Rosso
- Nicolas Chausson (ORCID: https://orcid.org/0000-0002-3512-1385)
- Julien Savatovsky (ORCID: https://orcid.org/0000-0002-6732-1779)
- Michaël Obadia (ORCID: https://orcid.org/0000-0001-6777-6311)
- Julien Rigal (ORCID: https://orcid.org/0000-0002-4217-9788)
- Jérémie Dassa
- François Lun (ORCID: https://orcid.org/0009-0000-1630-8411)
- Benjamin Maïer (ORCID: https://orcid.org/0000-0003-3993-1024)
- Philippe Casenave
- Sonia Alamowitch
- Isabelle Girard Buttaz
- Denis Sablot (ORCID: https://orcid.org/0000-0002-9038-7119)
- Julien Allard (ORCID: https://orcid.org/0000-0001-8017-6062)
- Gaspard Gerschenfeld (ORCID: https://orcid.org/0000-0002-2456-704X)
- Gaultier Marnat (ORCID: https://orcid.org/0000-0002-7611-7753)
- Anne Wacongne (ORCID: https://orcid.org/0000-0002-3976-3772)
- Tristan Benoit
- Frédéric Clarençon (ORCID: https://orcid.org/0000-0002-6442-8239)
- Wagih Ben Hassen (ORCID: https://orcid.org/0000-0003-4858-3623)
- Marie Belley
- Adrien ter Schiphorst (ORCID: https://orcid.org/0000-0002-7354-3351)
- Igor Sibon
- Olfa Kaaouana
- Caroline Arquizan (ORCID: https://orcid.org/0000-0001-7347-1039)
- Carole Henry (ORCID: https://orcid.org/0000-0002-5696-527X)
- Eric Manchon
- Romain Bourcier (ORCID: https://orcid.org/0000-0002-6506-4019)
- Jean‐Marc Olivot (ORCID: https://orcid.org/0000-0003-2027-2276)
- Loïc Legris
- Raphaël Blanc (ORCID: https://orcid.org/0000-0002-3975-3865)
- Géraud Forestier (ORCID: https://orcid.org/0000-0003-4797-9693)
- Jérémie Papassin
- Marion Yger (ORCID: https://orcid.org/0000-0001-6048-1393)
- Guillaume Turc
- Marc Guillaume
- Fernando Pico
- Vincent Costalat
- Michel Piotin
- Didier Smadja
- Bertrand Lapergue
- Jildaz Caroff
- Jean-Philippe Desilles
- Mikael Mazighi
- Julia Loeillot
- Stéphane Skerlak
- Florian Basille
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université de Versailles Saint-Quentin-en-Yvelines (FR)
- Université Paris Cité (FR)
- Université de Lille (FR)
- Université Paris-Saclay (FR)
- Centre Hospitalier Universitaire de Grenoble (FR)
- Centre Hospitalier Universitaire de Bordeaux (FR)
- Centre Hospitalier Universitaire de Lille (FR)
- Sorbonne Université (FR)
- Centre Hospitalier de Perpignan (FR)
- Institut des Sciences des Plantes de Paris Saclay (FR)
- Centre Hospitalier Universitaire Amiens-Picardie (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Centre hospitalier Emile Roux (FR)
- Open Window School of Visual Communication (ZA)
- Centre hospitalier de Rouffach (FR)
- Centre Hospitalier Universitaire de Nîmes (FR)
- Centre Hospitalier Métropole Savoie (FR)
- Hôpital Gui de Chauliac (FR)
- Centre Hospitalier Sud Francilien (FR)
- Centre Hospitalier Compiègne-Noyon (FR)
- Hôpital André Mignot (FR)
- Pitié-Salpêtrière Hospital (FR)
- Centre Hospitalier de Gonesse (FR)
- Centre Hospitalier Universitaire Notre Dame des Secours (LB)
- Groupe Hospitalier du Havre (FR)
- Fondation de Rothschild (FR)
- Open Window Productions (United States) (US)
- Centre Hospitalier Universitaire de Clermont-Ferrand (FR)
- Institut de Psychiatrie et Neurosciences de Paris (FR)
- Hôpitaux Universitaires Henri-Mondor (FR)
- Hôpital Paris Saint-Joseph (FR)
- Stanford Medicine (US)
- Institut du Thorax (FR)
- FHU Neurovasc (FR)
- Centre Hospitalier Saint-Denis (FR)
- Centre hospitalier Robert-Ballanger (FR)
- Grenoble Institute of Neurosciences (FR)
- Centre Hospitalier Universitaire de Rouen (FR)
- Centre Hospitalier de Valenciennes (FR)
- Centre Hospitalier Saint-Nazaire (FR)
- Bicêtre Hospital (FR)
- French Clinical Research Infrastructure Network (FR)
- Université de Rouen Normandie (FR)
- Université Grenoble Alpes (FR)
Publication Details
- Journal
- JAMA Neurology
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1001/jamaneurol.2025.4712
- Citations
- 1
- Primary Topic
- Trauma and Emergency Care Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.25