Immature neutrophils are elevated in human PGD and linked to G-CSF-driven injury in a murine model of lung ischemia–reperfusion
Our findings underscore the clinical significance of neutrophil heterogeneity in the early perioperative setting following LTx. Targeting the G-CSF-immature neutrophil axis may offer a novel strategy to improve early lung allograft outcomes.
Authors
- Mariano Paternoster (ORCID: https://orcid.org/0000-0002-3063-9839)
- A. Arjuna (ORCID: https://orcid.org/0000-0002-4171-3184)
- Davide Scozzi (ORCID: https://orcid.org/0000-0002-4049-1591)
- Ross Macrae Bremner (ORCID: https://orcid.org/0000-0003-2216-9109)
- Thalachallour Mohanakumar (ORCID: https://orcid.org/0000-0001-9873-4018)
- Jonathan Braat (ORCID: https://orcid.org/0009-0008-7822-0958)
- Michael A. Smith (ORCID: https://orcid.org/0009-0005-3694-3187)
- Rachel Klein (ORCID: https://orcid.org/0009-0003-1184-9181)
Institutions
- St. Joseph's Hospital and Medical Center (US)
- St. Joseph's Hospital (US)
Publication Details
- Journal
- The Journal of Heart and Lung Transplantation
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1016/j.healun.2025.11.030
- Citations
- 1
- Primary Topic
- Transplantation: Methods and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 2.01