Intragastric administration of Vitamin C and N-acetylcysteine mitigates computed tomography radiation-induced biological damage in rats
Oral Vitamin C and NAC significantly mitigate radiation exposure from CT imaging in rats. Both antioxidants effectively reduce γ-H2AX foci and micronucleus formation, offering substantial protection against radiation-induced DNA damage.
Authors
- Hongmei Gu (ORCID: https://orcid.org/0000-0002-8572-5435)
- Huimin Tao
- Long Jiang Zhang (ORCID: https://orcid.org/0000-0002-6664-7224)
- Minda Li
- Sheng Wang (ORCID: https://orcid.org/0000-0002-4797-5310)
- Yu Liu (ORCID: https://orcid.org/0000-0002-1402-0737)
- Jing Wang (ORCID: https://orcid.org/0009-0005-3735-734X)
- Guangming Lü
Institutions
- Soochow University (TW)
- Nantong University (CN)
- Nanjing General Hospital of Nanjing Military Command (CN)
- Soochow University (CN)
- Affiliated Hospital of Nantong University (CN)
- Ruihua Affiliated Hospital of Soochow University (CN)
- Second Affiliated Hospital of Soochow University (CN)
- First Affiliated Hospital of Soochow University (CN)
- Jinling Institute of Technology (CN)
- Nanjing University (CN)
Publication Details
- Journal
- International Journal of Radiation Biology
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1080/09553002.2025.2591790
- Primary Topic
- Vitamin C and Antioxidants Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00