A Computational Pathology Model to Predict Docetaxel Benefit in Localized High-Risk and Metastatic Prostate Cancer
APIC predicts docetaxel benefit in both metastatic and localized prostate cancers, independent of clinical factors. Validation in triplet therapy with androgen receptor pathway inhibitors is needed.
Authors
- Christopher J. Sweeney (ORCID: https://orcid.org/0000-0002-0398-6018)
- Shilpa Gupta (ORCID: https://orcid.org/0000-0002-8775-503X)
- Kamal Hammouda (ORCID: https://orcid.org/0000-0003-1598-4287)
- Tilak Pathak (ORCID: https://orcid.org/0000-0002-9738-4172)
- Michael Straza (ORCID: https://orcid.org/0000-0003-4672-6213)
- Anant Madabhushi (ORCID: https://orcid.org/0000-0002-5741-0399)
- Rohann Correa (ORCID: https://orcid.org/0000-0003-0886-1625)
- Tuomas Mirtti (ORCID: https://orcid.org/0000-0003-0455-9891)
- Amit Shah (ORCID: https://orcid.org/0009-0002-4759-3715)
- Howard M. Sandler (ORCID: https://orcid.org/0000-0002-8193-5769)
- Priti Lal (ORCID: https://orcid.org/0000-0002-5839-8205)
- Jason A. Efstathiou (ORCID: https://orcid.org/0000-0003-0996-0350)
- M.A. Hallman (ORCID: https://orcid.org/0000-0002-2825-0656)
- Pingfu Fu (ORCID: https://orcid.org/0000-0002-2334-5218)
- Richard C. Jordan (ORCID: https://orcid.org/0000-0002-2558-0537)
- Naoto Tokuyama (ORCID: https://orcid.org/0000-0002-7784-4901)
- Susan Chafe (ORCID: https://orcid.org/0009-0007-9227-7611)
- Sebastian Medina (ORCID: https://orcid.org/0000-0002-4154-0519)
- Karen Elizabeth Hoffman (ORCID: https://orcid.org/0000-0002-7316-8790)
- Stephanie L. Pugh (ORCID: https://orcid.org/0000-0002-5977-8912)
Institutions
- Cedars-Sinai Medical Center (US)
- Fox Chase Cancer Center (US)
- Cleveland Clinic (US)
- The University of Texas MD Anderson Cancer Center (US)
- Emory University (US)
- Mansoura University (EG)
- University of California, San Francisco (US)
- Federal Reserve Bank of San Francisco (US)
- Medical College of Wisconsin (US)
- Hospital of the University of Pennsylvania (US)
- Veterans Health Administration (US)
- Helsinki University Hospital (FI)
- London Health Sciences Centre (CA)
- The Wallace H. Coulter Department of Biomedical Engineering (US)
- Massachusetts General Hospital (US)
- WellSpan Health (US)
- Centre for Cancer Biology (AU)
- NRG Oncology (US)
- The University of Adelaide (AU)
- Case Western Reserve University (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-3327
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00