Bioinspired nanocomposite coatings for biomedical applications

Abstract The integration of biomedical devices within the human body is often challenged by issues such as poor biocompatibility, microbial infection, and inadequate interfacial bonding. Bioinspired nanocomposite coatings have emerged as a transformative strategy to engineer the surface of implants and medical devices, precisely tailoring their interactions with biological systems. This review comprehensively examines the recent advancements in the design, fabrication, and application of such coatings, drawing inspiration from natural paradigms like the lotus leaf, gecko feet, teeth, and bones. We discuss key material systems, including polymers, ceramics, and composites, and highlight fabrication techniques such as layer-by-layer assembly, physical and chemical vapor deposition, and bioinspired mineralization that enable precise control over surface topography, chemistry and physical properties. The manuscript delves into the mechanisms by which these nano-structured coatings enhance biomedical functionality, focusing on their roles in promoting specific cellular responses (e.g. osseointegration), imparting antibacterial properties, and improving corrosion resistance. Furthermore, we address the challenges of scalability, long-term stability, and regulatory hurdles. By critically analyzing the current state and future prospects, this review aims to provide a roadmap for the development of next-generation bioinspired coatings that significantly improve the success and longevity of biomedical implants and devices.