Intratumoral microbiota drive immune evasion and disease progression in oral squamous cell carcinoma
This study identified intratumoral microbial signatures as independent prognostic biomarkers and validated their reproducibility in an external cohort. Our findings support a microbiota-immune axis contributing to immune evasion in OSCC, offering novel avenues for prognostic stratification and therapeutic intervention.
Authors
- Xiaojie Zhang (ORCID: https://orcid.org/0000-0001-5615-0137)
- Xiaoxia Li (ORCID: https://orcid.org/0000-0002-5968-8271)
- Xiaolong Zang (ORCID: https://orcid.org/0000-0002-2556-1272)
- Rongxin Sun
- Zijian Cheng (ORCID: https://orcid.org/0000-0002-9184-3462)
- Zhiyong Li (ORCID: https://orcid.org/0000-0002-5082-5452)
Institutions
- Zhejiang University Medical College Affiliated Stomatological Hospital (CN)
- Stomatology Hospital (CN)
Publication Details
- Journal
- BDJ Open
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1038/s41405-025-00385-x
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Zhejiang Province