Multiorgan Fibrosis and Risk of Type 2 Diabetes: Genetic and Observational Evidence Highlighting a Causal Role of Pancreatic Fibrosis
Pancreatic, but not liver or myocardial, fibrosis is specifically and independently linked to type 2 diabetes. Mendelian randomization analysis reveals a causal role of pancreatic fibrosis in diabetes development. Pancreatic fibrosis might be a potential therapeutic target to preserve β-cell function and prevent diabetes.
Authors
- M Uchida (ORCID: https://orcid.org/0009-0003-3870-6543)
- Brian Z. Huang (ORCID: https://orcid.org/0000-0001-8645-5142)
- Sho Matsushita (ORCID: https://orcid.org/0000-0003-4810-1065)
- Hajime Yamazaki (ORCID: https://orcid.org/0000-0002-9034-4370)
- Martin Heni (ORCID: https://orcid.org/0000-0002-8462-3832)
- Róbert Wágner (ORCID: https://orcid.org/0000-0002-6120-0191)
- Yoji Hirayama (ORCID: https://orcid.org/0000-0003-1273-6210)
- Shoko Ariyoshi
- Sihao Han (ORCID: https://orcid.org/0000-0003-3433-3068)
- Ryosuke Horitani
Institutions
- University of Southern California (US)
- Fukushima Medical University (JP)
- Universität Ulm (DE)
- Kyoto University (JP)
- Düsseldorf University Hospital (DE)
- USC Norris Comprehensive Cancer Center (US)
- University Children's Hospital Tübingen (DE)
- Japan Community Healthcare Organization (JP)
- Deutsches Diabetes-Zentrum e.V. (DE)
- University Hospital Ulm (DE)
- Hashimoto Municipal Hospital (JP)
- German Center for Diabetes Research (DE)
- Heinrich Heine University Düsseldorf (DE)
- University of Tübingen (DE)
Publication Details
- Journal
- Diabetes
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2337/db25-0629
- Citations
- 1
- Primary Topic
- Pancreatitis Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.01