Exploratory analysis of epilepsy biomarkers using untargeted metabolomics across multiple cohorts
Several components of cell membranes were among the altered metabolites, indicating that cell membrane fluidity may have a significant role in the mechanism of epilepsy, and changes in lipid balance may indicate epilepsy. However, further studies are needed to evaluate whether untargeted metabolomics analysis could prove helpful in diagnosing epilepsy earlier.
Authors
- Monica H. Wojcik (ORCID: https://orcid.org/0000-0002-8162-5031)
- Sander Pajusalu (ORCID: https://orcid.org/0000-0002-5435-0781)
- Karit Reinson (ORCID: https://orcid.org/0000-0001-8235-2138)
- Adam D. Kennedy (ORCID: https://orcid.org/0000-0001-5391-9457)
- Katrin Õunap (ORCID: https://orcid.org/0000-0002-4594-6364)
- Mihkel Ilisson (ORCID: https://orcid.org/0000-0002-2228-9701)
- Toomas Haller (ORCID: https://orcid.org/0000-0002-5069-6523)
- Dmytro Fishman (ORCID: https://orcid.org/0000-0002-4644-8893)
- Laura Sommerville (ORCID: https://orcid.org/0000-0002-2556-1651)
- Eve Õiglane‐Shlik
- Kai Muru (ORCID: https://orcid.org/0000-0003-2518-6828)
- Tiia Reimand
- Kaisa Teele Oja (ORCID: https://orcid.org/0000-0002-7084-0238)
- Jaanika Kronberg (ORCID: https://orcid.org/0000-0003-2362-656X)
- Hedi Peterson (ORCID: https://orcid.org/0000-0001-9951-5116)
- Anne O’Donnell‐Luria (ORCID: https://orcid.org/0000-0001-6418-9592)
- Gregory A. Michelotti (ORCID: https://orcid.org/0000-0002-7908-1979)
Institutions
- Broad Institute (US)
- Boston Children's Hospital (US)
- Tartu University Hospital (EE)
- Metabolon (United States) (US)
- Software Technology and Applications Competence Center (EE)
- University of Tartu (EE)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2025-12-01
- DOI
- https://doi.org/10.3389/fneur.2025.1684456
- Citations
- 1
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Broad Institute
- Eesti Teadusagentuur
- European Regional Development Fund
- National Heart, Lung, and Blood Institute