Os Draconis-Derived Nanoparticles Improve Insomnia Symptoms by Activating Calcium-Dependent 5-HT Release and the Vagal-NTS Pathway
This is the first research to suggest that oral DOD is digested into OD-NPs, which are then internalized by enterochromaffin cells. This absorption initiates calcium signaling, boosts 5-HT release, and then activates the vagus nerve-NTS pathway, thereby regulating central nervous system activity. This research provides scientific proof for the clinical application of OD, lays the groundwork for the development of artificial alternatives, and generates ideas for future traditional Chinese medicine research.
Authors
- Chunjie Wu (ORCID: https://orcid.org/0000-0001-7496-8469)
- Yongliang Huang (ORCID: https://orcid.org/0000-0003-3651-9501)
- Xun Ye (ORCID: https://orcid.org/0000-0002-1321-0942)
- Xueling Fan (ORCID: https://orcid.org/0000-0002-9479-8652)
- Qian Wang (ORCID: https://orcid.org/0000-0002-6514-3470)
- Zheng Liu (ORCID: https://orcid.org/0000-0001-7765-8466)
- Qinyu Wang (ORCID: https://orcid.org/0009-0009-5704-135X)
Institutions
- Sichuan Animal Science Academy (CN)
- Chengdu Institute of Biology (CN)
- Sichuan Academy of Traditional Chinese Medicine (CN)
- Chengdu University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2147/ijn.s553405
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chengdu University of Traditional Chinese Medicine
- Chengdu University