Comparing the diagnostic accuracy of Afirma GSC to ThyroSeq V3 in cytologically indeterminate thyroid nodules
Both molecular tests demonstrate high NPV but low specificity; neither is clearly superior. Future research should prioritise randomised controlled trials, long-term follow-up of unoperated nodules, and direct comparisons of molecular tests.
Authors
- Mohammad Muzaffar
- Mahmuda Begum (ORCID: https://orcid.org/0000-0003-0908-5680)
- María del Mar Nieto
- Kristien Boelaert
- Miss Natasha Dowell (ORCID: https://orcid.org/0009-0002-3289-1656)
Institutions
- University Hospitals Birmingham NHS Foundation Trust (GB)
- University College Birmingham (GB)
- University of Birmingham (GB)
Publication Details
- Journal
- European Thyroid Journal
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1530/etj-25-0296
- Primary Topic
- Thyroid Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00