Early-onset gastrointestinal amyloid A amyloidosis without renal involvement in a patient with RA–pSpA overlap: A case report

This case illustrates early GI-dominant AA amyloidosis without renal involvement in RA-pSpA overlap. The coexistence of intense inflammatory responses and mucosal immune activation may predispose the GI tract to early amyloid deposition, emphasizing the need for active surveillance and early endoscopic evaluation in patients presenting with unexplained GI symptoms.