Organo-cation-catalyzed site-selective sequential alkylation of dimeric 2-oxindoles: a concise catalytic approach to (+)-calycanthidine and (+)-idiospermuline

The total synthesis of bis(cyclotryptamine) alkaloids has been realized via the development of an organo-cation-catalyzed (C5) site-selective, enantioselective (94% ee) and diastereoselective (dr > 20 : 1) sequential alkylation.

Authors

Saina Shaheeda MK
Debabrata Mondal (ORCID: https://orcid.org/0009-0007-8834-7525)
Alakesh Bisai (ORCID: https://orcid.org/0000-0001-5295-9756)
Arindam Khatua (ORCID: https://orcid.org/0000-0001-5847-5090)
Pranay Shyamal

Institutions

Indian Institute of Science Education and Research Kolkata (IN)
Indian Institute of Science Education and Research, Bhopal (IN)

Publication Details

Journal: Organic Chemistry Frontiers
Published: 2025-12-01
DOI: https://doi.org/10.1039/d5qo01482d
Primary Topic: Asymmetric Synthesis and Catalysis
Type: article
Field-Weighted Citation Impact: 0.00

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article

Organo-cation-catalyzed site-selective sequential alkylation of dimeric 2-oxindoles: a concise catalytic approach to (+)-calycanthidine and (+)-idiospermuline

Saina Shaheeda MK, Debabrata Mondal, Alakesh Bisai, Arindam Khatua et al.

Dec 1, 2025

Organic Chemistry Frontiers

Asymmetric Synthesis and Catalysis

article

Organo-cation-catalyzed site-selective sequential alkylation of dimeric 2-oxindoles: a concise catalytic approach to (+)-calycanthidine and (+)-idiospermuline

Saina Shaheeda MK, Debabrata Mondal, Alakesh Bisai, Arindam Khatua, Pranay Shyamal

December 1, 2025article en

Abstract

The total synthesis of bis(cyclotryptamine) alkaloids has been realized via the development of an organo-cation-catalyzed (C5) site-selective, enantioselective (94% ee) and diastereoselective (dr > 20 : 1) sequential alkylation.

Organic Chemistry FrontiersVol. 13(3)

Indian Institute of Science Education and Research Kolkata (IN), Indian Institute of Science Education and Research, Bhopal (IN)

Openalex Percentile: Top 72%

Asymmetric Synthesis and Catalysis

DOI Source OpenAlex

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Organo-cation-catalyzed site-selective sequential alkylation of dimeric 2-oxindoles: a concise catalytic approach to (+)-calycanthidine and (+)-idiospermuline — Saina Shaheeda MK, Debabrata Mondal, et al. · Organic Chemistry Frontiers (2025) | TGRS Research Map | TGRS