Efficacy and Safety of Pitolisant for Excessive Daytime Sleepiness in Narcolepsy and Obstructive Sleep Apnea: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials
Pitolisant significantly improves subjective and objective wakefulness and quality of life in EDS due to narcolepsy or OSA, with robust evidence for ESS benefit and a favorable safety profile.
Authors
- Syed Ibad Hussain (ORCID: https://orcid.org/0009-0007-4229-777X)
- Amna Amir Jalal (ORCID: https://orcid.org/0009-0005-5835-9811)
- Muhammad Saad Khan (ORCID: https://orcid.org/0009-0002-4228-6476)
- Asra Karim (ORCID: https://orcid.org/0009-0000-5540-1352)
- Harshika Khaim Chandani (ORCID: https://orcid.org/0009-0001-0191-1573)
- Shanza Shakir (ORCID: https://orcid.org/0009-0002-9994-3414)
- Erum Siddiqui (ORCID: https://orcid.org/0009-0006-7183-1022)
Institutions
- Liaquat University of Medical & Health Sciences (PK)
- Jinnah Sindh Medical University (PK)
Publication Details
- Journal
- Annals of Pharmacotherapy
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1177/10600280251390557
- Citations
- 1
- Primary Topic
- Sleep and Wakefulness Research
- Type
- article
- Field-Weighted Citation Impact
- 1.43