Beyond the Rash: a Review of Cutaneous Manifestation of Sexually Transmitted Infections

Abstract Purpose of Review Sexually transmitted infections (STIs) commonly present with cutaneous findings that can serve as important diagnostic clues. This review summarizes the dermatologic manifestations associated with a range of STIs, including bacterial, viral, fungal, and parasitic etiologies. Recent Findings Classic presentations such as syphilitic chancres, herpes simplex ulcers, and condyloma acuminata are discussed alongside emerging infections like Trichophyton mentagrophytes genotype VII and mpox. Recognition of these findings is essential, as skin manifestations may be the first indication of infection. Summary Timely identification and treatment of STI-related skin findings are critical for patient care and for interrupting transmission. As STI epidemiology evolves, clinicians must remain informed about both classic and atypical presentations of sexually transmitted skin disease to ensure accurate diagnosis, appropriate therapy, and effective public health intervention.