Retinal Pigment Epithelium Extracellular Vesicles Induce Microglia Polarization in <i>MERTK</i> -Associated Retinal Degeneration
RPE-derived EVs act as critical drivers of microglial M1 polarization in MERTK-associated RP. Our study revealed their pivotal role in the progression of early-onset severe RP, providing theoretical support for the potential of targeting EVs to modulate the retinal immune microenvironment and intervene in the progression of retinal degeneration.
Authors
- Lingzi Wu
- Jing Yuan (ORCID: https://orcid.org/0000-0003-0906-1822)
- Zi‐Bing Jin (ORCID: https://orcid.org/0000-0003-0515-698X)
- Xiao Zhang (ORCID: https://orcid.org/0000-0002-8213-6686)
- Zhenyu Liu (ORCID: https://orcid.org/0009-0007-0565-0781)
- Yang Li (ORCID: https://orcid.org/0000-0002-8734-4054)
- Hang Zhang (ORCID: https://orcid.org/0000-0002-2493-0806)
- Xiaohui Zhang (ORCID: https://orcid.org/0000-0001-6118-9992)
- Fei Liu (ORCID: https://orcid.org/0000-0002-9814-4226)
Institutions
- Brigham and Women's Hospital (US)
- Beijing Tongren Hospital (CN)
- Harvard University (US)
- Capital Medical University (CN)
- First Affiliated Hospital Zhejiang University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1167/iovs.66.15.1
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00