The role of substance P in Th17/Treg imbalance and ocular surface damage in chronic allergic conjunctivitis
Substance P contributes to persistent AC by disrupting the Th17/Treg equilibrium via STAT3/STAT5 signaling, thereby exacerbating ocular surface damage. Targeting the SP/NK1R pathway may offer a novel therapeutic approach for chronic AC.
Authors
- Fengyang Lei (ORCID: https://orcid.org/0000-0002-9169-8314)
- Binge Wu (ORCID: https://orcid.org/0000-0002-1933-8365)
- Xiaoniao Chen (ORCID: https://orcid.org/0000-0002-7620-4400)
- Jiayu Bao (ORCID: https://orcid.org/0000-0001-9476-3225)
- Ya Wen (ORCID: https://orcid.org/0009-0001-2339-5549)
- Siyuan Li (ORCID: https://orcid.org/0000-0002-8649-0623)
- Yaqiong Li (ORCID: https://orcid.org/0009-0001-6512-4392)
- Lei Tian (ORCID: https://orcid.org/0000-0002-7485-9366)
- Ying Jie (ORCID: https://orcid.org/0000-0003-2649-8241)
Institutions
- Beijing Tongren Hospital (CN)
- Chinese PLA General Hospital (CN)
- Inner Mongolia University of Science and Technology (CN)
- Baotou Medical College (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1186/s12967-025-07460-9
- Citations
- 2
- Primary Topic
- Neuropeptides and Animal Physiology
- Type
- article
- Field-Weighted Citation Impact
- 1.82