FREM1 serves as a novel therapeutic target in breast cancer through basement membrane-based prognostic modeling with integrated bioinformatics and experimental validation

Our study establishes BM-related genes as novel prognostic biomarkers and therapeutic targets in breast cancer. FREM1 in particular functions as a tumor suppressor by inhibiting cancer cell proliferation, migration, and invasion, highlighting its potential for therapeutic exploitation. These findings provide critical insights into BM-mediated tumor progression and suggest new avenues for targeted breast cancer therapy.