Mega-scale single-cell profiling reveals novel biomarkers associated with acute GvHD after allogeneic hematopoietic stem cell transplantation
In conclusion, mega-scale single-cell monitoring of graft and hematopoietic immune cell reconstitution allowed us to demonstrate that MDGA1 and ADGRG1 may function as complementary biomarkers expressed by distinct circulating T cells that are associated with divergent outcomes in AML patients, enabling precise risk stratification of alloHSCT outcomes and presenting potential therapeutic targets.
Authors
- Likai Tan (ORCID: https://orcid.org/0000-0001-7555-9472)
- Francis Ayuk
- Stefan Bonn (ORCID: https://orcid.org/0000-0003-4366-5662)
- Immo Prinz (ORCID: https://orcid.org/0000-0002-8789-9578)
- Kristin Rathje
- Sarina Ravens (ORCID: https://orcid.org/0000-0002-3265-6341)
- Nicola Gagliani (ORCID: https://orcid.org/0000-0001-8514-1395)
- Christian F. Krebs (ORCID: https://orcid.org/0000-0003-2739-5578)
- Anita Badbaran (ORCID: https://orcid.org/0000-0002-9993-0886)
- Radwan Massoud (ORCID: https://orcid.org/0000-0001-9275-3840)
- Boris Fehse (ORCID: https://orcid.org/0000-0001-9780-7211)
- Ulf Panzer (ORCID: https://orcid.org/0000-0001-9449-0722)
- Nico Gagelmann (ORCID: https://orcid.org/0000-0002-0891-1744)
- Anja Schimrock
- Christine Wolschke
- Silja Weßler (ORCID: https://orcid.org/0000-0001-7011-6162)
- Regine J. Dress (ORCID: https://orcid.org/0000-0001-8785-5471)
- Cedric Ly
- Evgeny Klyuchnikov (ORCID: https://orcid.org/0000-0001-9407-1413)
- Yu Zhang (ORCID: https://orcid.org/0000-0003-3474-422X)
- Zheng Song
- Nicolaus Kröger
- Emilia Czajkowski
Institutions
- Universität Hamburg (DE)
- Chinese University of Hong Kong (HK)
- Medizinische Hochschule Hannover (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- Prince of Wales Hospital (CN)
- Institute of Immunology (HR)
Publication Details
- Journal
- Biomarker Research
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1186/s40364-025-00868-x
- Primary Topic
- Hematopoietic Stem Cell Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft
- Universitätsklinikum Hamburg-Eppendorf