Individual and additive effects of childhood maltreatment and substance use disorder histories on baseline and stress-induced changes in peripheral stress biomarkers
Exposure to CM is associated with pro-inflammatory states at baseline and across stress exposure. Additionally, 2-AG may be a marker of SUD pathology in the absence of CM. However, no effect of CM or SUD status was found on KYN pathway metabolites. The mechanisms underlying elevated susceptibility to SUD following CM-exposure require further investigation.
Authors
- Andrea Johansson Capusan (ORCID: https://orcid.org/0000-0003-1758-2206)
- Elisabeth Paul (ORCID: https://orcid.org/0000-0002-0201-273X)
- Ryann Tansey (ORCID: https://orcid.org/0000-0002-6865-5893)
- Markus Heilig (ORCID: https://orcid.org/0000-0003-2706-2482)
- Margareta Östman (ORCID: https://orcid.org/0000-0002-0884-6161)
- Daniel Roche (ORCID: https://orcid.org/0000-0001-6298-1519)
- Leah M. Mayo
- Abigail R. Lunge
Institutions
- Linköping University (SE)
- University of Maryland, Baltimore (US)
- Allen Institute for Brain Science (US)
Publication Details
- Journal
- Psychopharmacology
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1007/s00213-025-06953-1
- Citations
- 1
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.58
Funders
- National Alliance for Research on Schizophrenia and Depression
- Linköpings Universitet
- Vetenskapsrådet