Tracking Natural Science Objects and Their Physical and Digital Derivatives in DINA

Provenance plays an important role in natural history collections, but capturing this information accurately, proved challenging for legacy digital collection management systems. DINA*1 is being developed to address these limitations through a process-oriented data model that more effectively captures the complexity and context of provenance information (Bölling et al. 2022). DINA is an open-source, robust sample- and specimen-based collection management system in production and developed by an unincorporated international consortium of technologists and practitioners of the natural sciences (Glöckler et al. 2020). Its governance and data models help to foster the adoption of FAIR principles (Findable, Accessible, Interopable, Reusable) and to integrate objects across science domains. DINA's innovative "samplistic" data model records metadata on stepwise, hierarchical processes that generate physical and digital derivatives from parent material samples, accommodating complex real-life sample trajectories, for example: A fossil specimen is acquired by a museum, which contains the remains of several organisms in hardened resin. Later, it is sawed into smaller pieces; some pieces are stored under new catalog numbers, a tiny piece is sent for a destructive C14 (radioactive carbon) analysis (Fig. 1 a). A naturally deceased individual of a mammal species is collected under a material transfer agreement (MTA). Later, subsamples like teeth, bones, and tissues undergo different preparation and preservation processes and are finally stored in specialized collections, each with its own identifier (scheme); a subsample might even be retrieved for sequencing. Strong provenance tracking is required to ensure that regulatory constraints like the MTA are consistently passed down to any derivatives. A soil core is collected from a sampling site and registered together with observational metadata according to the MIxS (Minimum Information about Any Sequence) soil extension standard. Several subsamples are extracted before the remaining core is preserved. The subsamples are subjected to DNA extraction and sequencing to analyze environmental DNA (eDNA). The resulting sequences are then processed computationally to identify the species present (Fig. 1 b). A fossil specimen is acquired by a museum, which contains the remains of several organisms in hardened resin. Later, it is sawed into smaller pieces; some pieces are stored under new catalog numbers, a tiny piece is sent for a destructive C14 (radioactive carbon) analysis (Fig. 1 a). A naturally deceased individual of a mammal species is collected under a material transfer agreement (MTA). Later, subsamples like teeth, bones, and tissues undergo different preparation and preservation processes and are finally stored in specialized collections, each with its own identifier (scheme); a subsample might even be retrieved for sequencing. Strong provenance tracking is required to ensure that regulatory constraints like the MTA are consistently passed down to any derivatives. A soil core is collected from a sampling site and registered together with observational metadata according to the MIxS (Minimum Information about Any Sequence) soil extension standard. Several subsamples are extracted before the remaining core is preserved. The subsamples are subjected to DNA extraction and sequencing to analyze environmental DNA (eDNA). The resulting sequences are then processed computationally to identify the species present (Fig. 1 b). In all examples, the processing history of each subsample can be modeled in DINA so provenance can always be traced back to the original sample. Knowledge from any derivative analysis can be linked back to the parent sample and other derivatives. This ensures that regulatory restrictions applying to a parent material sample are passed down consistently. Besides parent-child relationships, the model can represent other associations, e.g., host, parasite, and vector relationships linking samples in different collections. Each sample in the provenance chain, as well as first-class related objects like projects, collections, events, people, protocols, and storage, has a system-defined globally unique identifier. DINA integrates with external systems where possible via persistent identifiers, including reuse of scientific names from community-curated biodiversity sources through the Global Names Architecture. DINA’s application programming interface simplifies data import and migration and can be used by scientific programming languages like Python or R to access data objects or their relationships. Flexible user-defined “managed attributes” enhance object and derivative metadata when standards do not yet exist. When standards like MIxS or MIDS (Minimum Information about a Digital Specimen) exist, these are incorporated as field extensions. Looking ahead, we aim to further strengthen linkages and provenance tracking in DINA, extending support to model complex bio-geo relationships and enhancing linkage of material samples to external resources such as publications.