Synergistic and heterogeneous aging using composite phenotypes and multiple organ systems aging clocks
The overlap between composite phenotypes and biological age provides valuable insights into multi-phenotypic aging. The unearthing of the heterogeneity in aging processes could further inform the development of personalized interventions to slow organ-specific aging and better manage age-related health problems.
Authors
- Zhenqiu Liu (ORCID: https://orcid.org/0000-0002-5244-6894)
- Ningxin Gao
- Yucan Li (ORCID: https://orcid.org/0000-0002-9778-9057)
- Danke Wang
- Mei Cui (ORCID: https://orcid.org/0000-0002-6449-8106)
- Kelin Xu (ORCID: https://orcid.org/0000-0002-6788-4256)
- Yi Zheng (ORCID: https://orcid.org/0000-0002-8996-9840)
- Tiejun Zhang (ORCID: https://orcid.org/0000-0002-9591-0650)
- Xingdong Chen (ORCID: https://orcid.org/0000-0003-3763-160X)
- Xinming Xu (ORCID: https://orcid.org/0009-0005-3121-8138)
- Yanfeng Jiang (ORCID: https://orcid.org/0000-0003-3497-181X)
- Xin Zhang (ORCID: https://orcid.org/0000-0001-9511-4737)
- Yawen Wang (ORCID: https://orcid.org/0000-0002-1306-8931)
- Rui Li (ORCID: https://orcid.org/0000-0003-2318-9232)
- Jianming Wang
- Jincheng Li (ORCID: https://orcid.org/0000-0003-4550-2808)
- Jialin Li (ORCID: https://orcid.org/0000-0001-6930-9530)
- Yingzhe Wang (ORCID: https://orcid.org/0000-0002-8401-2644)
- Jiacheng Wang (ORCID: https://orcid.org/0000-0003-0738-4732)
Institutions
- Fudan University (CN)
- Ministry of Education (KR)
- Yiwu Science and Technology Research Institute (CN)
- Huashan Hospital (CN)
- Taizhou University (CN)
Publication Details
- Journal
- Communications Medicine
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1038/s43856-025-01222-w
- Primary Topic
- Genetics, Aging, and Longevity in Model Organisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Shanghai
- National Natural Science Foundation of China