FFAR4 drives stem cell fate toward lipid- and iron-storing enterocytes protecting human enteroids from ferroptosis
Altogether, our findings show that chemosensory receptors on stem cells play a more influential role than previously appreciated in modulating gut epithelial composition and function in response to environmental cues.
Authors
- Marc Ferrante (ORCID: https://orcid.org/0000-0003-1492-0716)
- Ellen Deleus (ORCID: https://orcid.org/0000-0002-8496-7723)
- Theo Thijs (ORCID: https://orcid.org/0000-0001-5226-2633)
- Inge Depoortere (ORCID: https://orcid.org/0000-0002-0289-2175)
- Hui Leng
- Laurens J. Ceulemans (ORCID: https://orcid.org/0000-0002-4261-7100)
- Mona Farhadipour (ORCID: https://orcid.org/0000-0002-8454-2856)
- Matthias Lannoo (ORCID: https://orcid.org/0000-0001-7815-1157)
- Bart Van der Schueren (ORCID: https://orcid.org/0000-0003-4754-784X)
- Antoine Dubois (ORCID: https://orcid.org/0000-0002-2839-8896)
Institutions
- KU Leuven (BE)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1186/s13287-025-04840-2
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- KU Leuven