Heparin decreases serum sphingosine-1-phosphate levels in patients with vascular diseases
Circulating S1P concentrations in patients with atherosclerosis are associated to different blood components before and after interventions. Reduced postoperative serum S1P levels in patients are most likely attributed to heparin treatment. The causalities between heparin treatment, reduced serum S1P and reduced intimal hyperplasia deserve further investigations.
Authors
- E. Oetjen (ORCID: https://orcid.org/0000-0001-7807-6652)
- Mirjam von Lucadou
- Yu Jiang (ORCID: https://orcid.org/0000-0001-7344-7274)
- A. Larena-Avellaneda
- Rainer H. Böger (ORCID: https://orcid.org/0000-0003-3770-5357)
- Edzard Schwedhelm (ORCID: https://orcid.org/0000-0003-3597-6276)
- Markus Geissen (ORCID: https://orcid.org/0009-0004-0393-8018)
- Justus M. Grewe (ORCID: https://orcid.org/0000-0002-9249-9202)
- E. Sebastian Debus (ORCID: https://orcid.org/0000-0002-5664-6439)
- Yi Qin (ORCID: https://orcid.org/0000-0002-1160-3240)
- Lea Wegmann
- Günter Daum
Institutions
- Universität Hamburg (DE)
- Asklepios Klinik Altona (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- German Centre for Cardiovascular Research (DE)
Publication Details
- Journal
- Atherosclerosis
- Published
- 2025-11-22
- DOI
- https://doi.org/10.1016/j.atherosclerosis.2025.120593
- Primary Topic
- Sphingolipid Metabolism and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00