Saliva from oral squamous cell carcinoma patients promotes tumor progression via Inflammation, stromal remodeling, and metabolic reprogramming in a mouse model
This study demonstrates that saliva from OSCC patients promotes tumor progression in vivo through a multifactorial mechanism involving inflammation, stromal remodeling, and metabolic rewiring. These findings highlight the tumor-promoting potential of salivary and microbial components, suggesting new avenues for diagnostic and therapeutic strategies targeting the oral microenvironment in OSCC.
Authors
- Haibing Yin
- Xiang Ding
- Shihan Zhang (ORCID: https://orcid.org/0000-0002-2377-5760)
- Yu Gao (ORCID: https://orcid.org/0000-0003-3877-2439)
- Beibei Liang (ORCID: https://orcid.org/0000-0002-5363-6315)
- Xiaoyan Zhang (ORCID: https://orcid.org/0000-0002-3193-1401)
- Ying Feng (ORCID: https://orcid.org/0000-0003-1045-4172)
- Jie Guo (ORCID: https://orcid.org/0000-0002-2965-0467)
- Yuantao Li (ORCID: https://orcid.org/0000-0003-4531-7864)
- Xiangjun Li (ORCID: https://orcid.org/0000-0002-8986-7203)
- Qian Han
Institutions
- Hebei Medical University (CN)
- Hospital of Hebei Province (CN)
- Fourth Hospital of Hebei Medical University (CN)
- Jining Traditional Chinese Medicine Hospital (CN)
- Hebei University of Chinese Medicine (CN)
- Hebei Science and Technology Department (CN)
Publication Details
- Journal
- BMC Oral Health
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1186/s12903-025-07413-0
- Primary Topic
- Salivary Gland Disorders and Functions
- Type
- article
- Field-Weighted Citation Impact
- 0.00