Comparison of Efficacy and Safety of Colistimethate Sodium and Polymyxin B in the Treatment of Bloodstream Infection Caused by Carbapenem-Resistant Gram-Negative Bacteria: A Retrospective Study
This study provides the first large, real-world comparative evidence from a Chinese cohort with CR-GNB BSIs. In this setting, CMS and PMB demonstrated comparable efficacy. The critical difference lay in the safety profile, with CMS associated with a markedly lower incidence of hyperpigmentation. This finding provides a tangible basis for antibiotic stewardship, positioning CMS as a valuable first-line polymyxin option.
Authors
- Jun Jin (ORCID: https://orcid.org/0000-0001-9751-1293)
- Daguo Zhao (ORCID: https://orcid.org/0000-0003-1969-4789)
- Jindan Kong
- Fang Huang (ORCID: https://orcid.org/0000-0002-2227-4761)
- Yan Hao
- Dongrong Li
- Jun Wang (ORCID: https://orcid.org/0000-0001-8708-3096)
- Jing Li (ORCID: https://orcid.org/0000-0002-1361-4525)
- Shifeng Li
- Hua Xu (ORCID: https://orcid.org/0000-0003-3295-061X)
- Xiangqiong Lu
Institutions
- Soochow University (CN)
- First Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- Infection and Drug Resistance
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2147/idr.s555233
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Jiangsu Commission of Health