Predictive value of tumor marker index for pathological complete response following neoadjuvant chemoradiotherapy in locally advanced rectal cancer
Pre-treatment TMI is an independent predictor of pCR and correlates with lower recurrence in LARC after nCRT. Given its high sensitivity/NPV at the identified threshold, TMI may support organ-preservation discussions and guide treatment intensification strategies; prospective validation is warranted.
Authors
- Ali Murat Tatlı (ORCID: https://orcid.org/0000-0001-9696-1102)
- Mustafa Özdoğan (ORCID: https://orcid.org/0000-0002-4297-3607)
- Selami Bayram (ORCID: https://orcid.org/0000-0002-0930-5025)
- Mustafa Serkan Alemdar (ORCID: https://orcid.org/0000-0002-7663-6182)
Institutions
- Antalya Eğitim ve Araştırma Hastanesi (TR)
- Antalya IVF (TR)
Publication Details
- Journal
- World Journal of Surgical Oncology
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1186/s12957-025-04081-w
- Primary Topic
- Colorectal Cancer Surgical Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00