Integrative prognostic model incorporating high mobility group box 1 subcellular localization and tumor-infiltrating lymphocytes in early-stage lung adenocarcinoma
HMGB1 subcellular localization and TIL infiltration are independent prognostic biomarkers of early-stage lung adenocarcinoma. An integrative model combining these parameters provides enhanced risk stratification and may inform individualized postoperative management strategies.
Authors
- Sohsuke Yamada (ORCID: https://orcid.org/0000-0003-2662-0024)
- Motona Kumagai (ORCID: https://orcid.org/0009-0007-8979-3981)
- Jia Han (ORCID: https://orcid.org/0000-0003-0108-996X)
- Hidetaka Uramoto (ORCID: https://orcid.org/0000-0003-4451-4225)
- Miyako Shimasaki (ORCID: https://orcid.org/0009-0001-0900-5938)
- Masaru Sakurai (ORCID: https://orcid.org/0000-0002-4929-3225)
- Akihiro Shioya (ORCID: https://orcid.org/0000-0002-1863-5368)
- Yao Liu (ORCID: https://orcid.org/0000-0001-9794-1314)
Institutions
- Hebei Medical University (CN)
- Kanazawa Medical University (JP)
- Fourth Hospital of Hebei Medical University (CN)
- Kanazawa Medical University Hospital (JP)
Publication Details
- Journal
- Diagnostic Pathology
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1186/s13000-025-01736-w
- Primary Topic
- Advanced Glycation End Products research
- Type
- article
- Field-Weighted Citation Impact
- 0.00