Mediterranean diet, gut microbiota, and cognitive decline in older adults with obesity/overweight and metabolic syndrome: a prospective cohort study
Greater adherence to the MedDiet was associated with a favorable gut microbiota profile and slower cognitive decline over 6-year of follow-up. A microbiome-derived signature of MedDiet adherence was prospectively associated with favorable cognitive trajectories in older adults at risk of cognitive decline. External validation and experimental research are warranted to translate these findings into targeted microbiome-based dietary interventions for healthy cognitive aging.
Authors
- Isabel Moreno‐Indias (ORCID: https://orcid.org/0000-0002-6121-151X)
- Montserrat Fitó (ORCID: https://orcid.org/0000-0002-1817-483X)
- Dolores Corella (ORCID: https://orcid.org/0000-0002-2366-4104)
- Miguel Ruiz‐Canela (ORCID: https://orcid.org/0000-0002-7684-2787)
- Jiaqi Ni (ORCID: https://orcid.org/0000-0001-5625-0373)
- Clara Belzer (ORCID: https://orcid.org/0000-0001-6922-836X)
- Jesús Vioqué (ORCID: https://orcid.org/0000-0002-2284-148X)
- Laura Torres‐Collado (ORCID: https://orcid.org/0000-0003-2842-1344)
- Francisco José Tinahones (ORCID: https://orcid.org/0000-0001-6871-4403)
- Óscar Coltell (ORCID: https://orcid.org/0000-0002-4518-8495)
- Olga Castañer (ORCID: https://orcid.org/0000-0003-3169-997X)
- Stephanie Nishi (ORCID: https://orcid.org/0000-0002-7878-5368)
- Dong D. Wang (ORCID: https://orcid.org/0000-0002-0897-3048)
- Adrián Hernández-Cacho (ORCID: https://orcid.org/0000-0002-5250-1048)
- Nancy Babio
- Josep Juan Vidal
- Jordi Salas-Salvadó
- Prokopis Konstati
Institutions
- Broad Institute (US)
- Universitat Jaume I (ES)
- Universitat de Miguel Hernández d'Elx (ES)
- Brigham and Women's Hospital (US)
- St. Michael's Hospital (CA)
- Harvard University (US)
- Universitat de València (ES)
- University of Toronto (CA)
- Instituto de Salud Carlos III (ES)
- Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas (ES)
- Departament de Salut (ES)
- Institut de Recerca Biomèdica Catalunya Sud (ES)
- Navarre Institute of Health Research (ES)
- Hospital Del Mar (ES)
- Municipal Institute for Medical Research (ES)
- St Michael’s Hospital (GB)
- Hospital Clínico Universitario Virgen de la Victoria (ES)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Instituto de Investigación Biomédica de Málaga (ES)
- Universitat Rovira i Virgili (ES)
- Universidad de Málaga (ES)
- Wageningen University & Research (NL)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1186/s12916-025-04488-y
- Citations
- 2
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Almond Board of California
- Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas
- Instituto de Salud Carlos III