Joint association of inflammatory markers and sedentary time with mortality in metabolic dysfunction-associated steatotic liver disease population and the mediating role of inflammation
In U.S. adults with a high probability of MASLD identified by the FLI, both longer sedentary time and elevated systemic inflammation level are linked to increased risks of all-cause and CVD mortality. Moreover, inflammation statistically explains part of this association. These findings highlight the importance of reducing sedentary time and managing systemic inflammation to improve outcomes in individuals with FLI-defined MASLD.
Authors
- Yufeng Xing (ORCID: https://orcid.org/0000-0001-6762-3788)
- Zhijian Gong
- Liubin Xu (ORCID: https://orcid.org/0000-0001-5463-2562)
- Huili Yang
- Jing Chen (ORCID: https://orcid.org/0000-0003-2434-0010)
- Congcong Shi
- Xinyu Hu (ORCID: https://orcid.org/0009-0009-7265-2730)
- Lian Feng (ORCID: https://orcid.org/0000-0002-1995-6366)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Chinese University of Hong Kong, Shenzhen (CN)
- Shenzhen Second People's Hospital (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1186/s40001-025-03486-3
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Centers for Disease Control and Prevention
- Sanming Project of Medicine in Shenzhen