Exploratory analysis of the molecular and genomic landscape of upper tract urothelial carcinoma using long-read sequencing
The analysis revealed multiple genetic variants potentially associated with UTUC carcinogenesis or development, and indicated advantages of TGS over next-generation sequencing (NGS) in cancer genetic variant detection, especially in SV and Short Tandem Repeats (STRs). This study may lay the groundwork for molecular classification and offer valuable insights into the development of precision therapies for UTUC.
Authors
- Shengming Jin (ORCID: https://orcid.org/0000-0001-8666-4606)
- Dingwei Ye (ORCID: https://orcid.org/0000-0001-7770-9753)
- Xiaoyang Ling (ORCID: https://orcid.org/0009-0002-7615-6063)
- Junlong Wu (ORCID: https://orcid.org/0000-0002-4125-7975)
- Zhenhua Cao (ORCID: https://orcid.org/0000-0002-5247-8896)
- Zhi Shang (ORCID: https://orcid.org/0000-0002-1413-0039)
Institutions
- Shanghai Medical College of Fudan University (CN)
- Fudan University Shanghai Cancer Center (CN)
- Shanghai Cancer Institute (CN)
- Yebio Bioengineering (China) (CN)
- Bioengineering Center (RU)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1186/s12885-025-15254-x
- Primary Topic
- Bladder and Urothelial Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Beijing Xisike Clinical Oncology Research Foundation