Ceftriaxone alleviates mitochondrial damage through the inhibition of extrasynaptic NMDA receptor-mediated changes in intracellular calcium levels to improve cognitive deficits in APP/PS1 mice
Cef treatment prevented the upregulation of eNMDAR expression and the subsequent extracellular calcium influx in a GLT-1-dependent manner, thereby reducing mitochondrial calcium loading and ultimately mitigating mitochondrial damage and cognitive deficits in APP/PS1 mice.
Authors
- Lizhe Liu (ORCID: https://orcid.org/0000-0001-5111-0750)
- He Li (ORCID: https://orcid.org/0000-0001-9345-042X)
- Li Li (ORCID: https://orcid.org/0000-0001-6131-4394)
- Wenbin Li (ORCID: https://orcid.org/0000-0003-3096-4831)
- Xiao‐Hui Xian (ORCID: https://orcid.org/0000-0002-0786-3373)
- Ruo-Bing He
- Lirong Liu (ORCID: https://orcid.org/0009-0006-9942-9166)
- Lili Lu (ORCID: https://orcid.org/0000-0002-3961-7214)
- Shujuan Fan
Institutions
- Hebei Medical University (CN)
- Third Hospital of Hebei Medical University (CN)
- Second Hospital of Hebei Medical University (CN)
- First Hospital of Shijiazhuang (CN)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1186/s13195-025-01900-w
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hebei Province