Heavy metal mixtures exposure and breast cancer risk: synergistic effects with SHBG identified by mediation and moderation models
Heavy metal exposure (particularly Pb) is associated with increased BC risk, potentially through SHBG upregulation and synergistic interactions, while Mn examines inverse associations. These findings highlight a potential link between environmental metals and hormone-related BC risk.
Authors
- Xingwang Zhu (ORCID: https://orcid.org/0000-0003-4936-967X)
- Mingyuan Xin (ORCID: https://orcid.org/0000-0001-9336-5612)
- Guole Nie (ORCID: https://orcid.org/0000-0001-6313-5357)
- Jun Yan (ORCID: https://orcid.org/0000-0003-4848-9952)
- Chunping Liu
- Tingting Wang (ORCID: https://orcid.org/0000-0002-6328-8115)
- Haijun Zhang (ORCID: https://orcid.org/0000-0002-3686-6346)
- Honglong Zhang (ORCID: https://orcid.org/0000-0001-9013-4237)
- Ruipeng Wang (ORCID: https://orcid.org/0000-0001-8661-4078)
Institutions
- Union Hospital (HK)
- Shandong University of Aeronautics (CN)
- First Hospital of Lanzhou University (CN)
- Huazhong University of Science and Technology (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- BMC Public Health
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1186/s12889-025-25590-z
- Primary Topic
- Heavy Metal Exposure and Toxicity
- Type
- article
- Field-Weighted Citation Impact
- 0.00