Efficacy of artemether-lumefantrine, dihydroartemisinin-piperaquine, and artesunate-pyronaridine for the treatment of uncomplicated Plasmodium falciparum malaria in Burkina Faso, 2020–2021
Continued low uncorrected efficacy of AL was observed in all sites, with one half to one third of children returning to the clinic with repeat infection within 28 days. PCR-corrected efficacy was at or below 90% for AL. AS-PYR and DP were associated with low rates of recurrent parasitaemia suggesting a potential for implementing a multiple first-line therapy approach with non-AL ACT. This approach will allow to preserve future use of lumefantrine and improve patient outcomes.
Authors
- Innocent Valéa (ORCID: https://orcid.org/0000-0002-3085-0490)
- Rene Kinda
- Adama Gansané
- Casimir Tarama
- Salif Sombié (ORCID: https://orcid.org/0000-0003-2893-836X)
- Jessica N. McCaffery (ORCID: https://orcid.org/0000-0002-7189-8706)
- Toussaint Rouamba
- Halidou Tinto (ORCID: https://orcid.org/0000-0002-0472-3586)
- Edwin Pierre-Louis (ORCID: https://orcid.org/0000-0001-9514-2498)
- Stefano Rosillo
- Leah F. Moriarty (ORCID: https://orcid.org/0000-0002-7836-1119)
- Jehan Ahmed
- Moussa Lingani (ORCID: https://orcid.org/0000-0002-5651-2035)
- Marko Bajic (ORCID: https://orcid.org/0000-0002-8566-5153)
- Christian S. Kompaore
- Lubbe Wiesner (ORCID: https://orcid.org/0000-0002-9070-8699)
- Dhruviben Patel
- Henri Somé
- Mateusz M. Pluciński (ORCID: https://orcid.org/0000-0002-7322-4625)
- Siaka Débé (ORCID: https://orcid.org/0000-0002-4192-2111)
- Charlotte Eddis
- Aladari Sagnon
- A. Ganou
- Gauthier Tougri
- Massa Achille Bonko
- Breanna Horton
- Farida Tiendrebeogo
- Alfred J. Kahn
- C. C. Kennedy
- Veronika R. Laird
- Seraphine Kiendrebeogo
Institutions
- Oak Ridge Associated Universities (US)
- Centers for Disease Control and Prevention (US)
- Emory University (US)
- University of Cape Town (ZA)
- U.S. President's Malaria Initiative (US)
- The Centers (US)
- Centre National de Recherche et de Formation sur le Paludisme (BF)
- Institut de Recherche en Sciences de la Santé (BF)
Publication Details
- Journal
- Malaria Journal
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1186/s12936-025-05693-z
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 0.00