An Update to the Clinical Pharmacogenetics Implementation Consortium ( <scp>CPIC</scp> ) <i>SLCO1B1</i> Allele Functionality Table Leveraging Evidence from Participants of Predominantly Sub‐Saharan African Ancestry
The Clinical Pharmacogenetics Implementation Consortium (CPIC) has formally updated the SLCO1B1 allele functionality table based on new evidence. Notably, the alleles studied (SLCO1B1 *9, *31, *41) are enriched in the genomes of patients historically excluded from pharmacogenomics research. This perspective illustrates how new evidence can advance clinical pharmacogenetics implementation guidelines incorporation in real time through collaboration with CPIC. Together, we can accelerate the translation of pharmacogenetics into a tool that truly improves health outcomes for everyone.
Authors
- Richard B. Kim (ORCID: https://orcid.org/0000-0001-8148-1632)
- Michelle Whirl‐Carrillo (ORCID: https://orcid.org/0000-0003-2414-9312)
- Akinyemi Oni‐Orisan (ORCID: https://orcid.org/0000-0002-5897-5543)
- Sook Wah Yee (ORCID: https://orcid.org/0000-0001-8121-8746)
- Tanushree Haldar (ORCID: https://orcid.org/0000-0002-5425-1230)
- Deepak Voora (ORCID: https://orcid.org/0000-0003-0015-5179)
- Kelly E. Caudle (ORCID: https://orcid.org/0000-0002-5663-3793)
Institutions
- Western University (CA)
- St. Jude Children's Research Hospital (US)
- University of California, San Francisco (US)
- Pfizer (United States) (US)
- Durham VA Medical Center (US)
- Stanford University (US)
Publication Details
- Journal
- Clinical Pharmacology & Therapeutics
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/cpt.70153
- Primary Topic
- Pharmacogenetics and Drug Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00