Evaluation of Efficacy of Topical Diphenylcyclopropenone in Treatment of Verrucae Vulgaris

Background: Verruca vulgaris is commonly associated with human papillomavirus (HPV) subtypes 2 and 4 and affects approximately 10% of the population. In adults, warts are less likely to resolve spontaneously and are more resistant to treatment. Moreover, immunosuppressed individuals have an increased burden of warts compared with immunocompetent patients. The first-line treatment for warts includes salicylic acid and cryotherapy; however, their efficacy rates range from 0% to 80% and 14% to 90%, respectively. objevtives:. This article aims to demonstrate efficacy and safety of contact immune sensitizers in treatment of verrucae vulgaris. Conclusions: Dinitrochlorobenzene, squaric acid dibutylester, and diphenylcyclopropenone are three substances that have demonstrated efficacy in the treatment of wart. Diphenylcyclopropenone provids a good option for the treatment of warts, and this treatment could be considered as an initial treatment option for patients who wish to avoid treatment-related pain and subsequent side effects, especially children or patients with large numbers of warts