Bioactive Secondary Metabolites from Marine Bacteria

Marine samples were collected from the Red Sea beach in Hurghada, Egypt, and processed within 24 hours. A total of 20 bacterial isolates were obtained from water samples and coded accordingly. These isolates were cultured in SP2 media for small-scale fermentation, and bioactive compounds were extracted using ethyl acetate. The crude extracts were tested for antimicrobial and antifungal activities against Escherichia coli, Staphylococcus aureus, Aspergillus niger, and Candida albicans.Antimicrobial screening revealed that all 20 isolates exhibited inhibitory effects against E. coli and S. aureus, with H1 demonstrating the highest inhibition (85.34%) against S. aureus. The antifungal activity assessment indicated that Es1 was the most potent against Aspergillus niger (81.78%), while B3 showed the highest activity against Candida albicans (82.7%) . These findings highlight the potential of marine bacteria as sources of bioactive compounds with promising antimicrobial and antifungal properties, warranting further characterization and optimization for potential pharmaceutical applications .