TLR4 Induces PANoptosis in Annulus Fibrosus Cells by Activating NLRP12 in Intervertebral Disc Degeneration
TLR4 promotes PANoptosis in AFCs through NLRP12 activation, driving IVDD pathogenesis. The TLR4-NLRP12-PANoptosis presents a potential therapeutic target for IVDD.
Authors
- Liang Cao (ORCID: https://orcid.org/0000-0001-7293-8338)
- Jiawei Fu
- W. Yue (ORCID: https://orcid.org/0009-0001-7483-760X)
- Bo Chen (ORCID: https://orcid.org/0000-0002-9926-4377)
- Chenhao Liu (ORCID: https://orcid.org/0000-0003-2769-9571)
- Feng Zheng (ORCID: https://orcid.org/0009-0001-7190-5814)
- Yulin Ma (ORCID: https://orcid.org/0000-0003-1764-0330)
- Menglin Luo (ORCID: https://orcid.org/0009-0007-3488-6697)
- Yu Zhai
Institutions
- Army Medical University (CN)
- Dalian Medical University (CN)
- Qinghai No.3 People's Hospital (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- Hebei Mental Health Center (CN)
- Qinghai Provincial Peoples Hospital (CN)
- First People's Hospital of Chongqing (CN)
- Baoding People's Hospital (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2147/jir.s556950
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00