Synthesis, Characterization, and Biological Activity of Benzothiazole Thioether Derivatives

Objective: Benzothiazole derivatives linked to coumarin exhibit a broad spectrum of biological activities. Based on this rationale, we synthesized several compounds containing triheterocyclic structures, which are connected via a methine (–CH) group and also feature a biologically relevant thioether bond (–C–S). Methods: We used L-proline as a catalyst in a multicomponent one-pot synthesis. The structures of the synthesized compounds were confirmed by various instrumental techniques, including IR, 1H, 13C NMR, and mass spectrometry. Results and Discussion: The obtained benzothiazole thioether derivatives were screened for antibacterial activity against Eю coli and Sю aureus using the zone of inhibition method. Compounds IVa and IVc exhibited promising antibacterial activity. Conclusions: The synthesized benzothiazole thioether derivatives show potential antibacterial activity, particularly compounds IVa and IVc.